By Jacqueline A. Hubbard,Devin K. Binder
Epilepsy is a devastating staff of neurological problems characterised by means of periodic and unpredictable seizure job within the mind. there's a serious want for brand new medications and techniques given than a minimum of one-third of all epilepsy sufferers aren't made freed from seizures by way of current medicinal drugs and develop into "medically refractory". a lot of epilepsy study has keen on neuronal healing ambitions, yet present antiepileptic medicines usually reason serious cognitive, developmental, and behavioral uncomfortable side effects. contemporary findings point out a serious contribution of astrocytes, star-shaped glial cells within the mind, to neuronal and community excitability and seizure task. additionally, many very important mobile and molecular adjustments happen in astrocytes in epileptic tissue in either people and animal types of epilepsy. The target of Astrocytes and Epilepsy is to comprehensively assessment intriguing findings linking alterations in astrocytes to practical alterations answerable for epilepsy for the 1st time in booklet layout. those insights into astrocyte contribution to seizure susceptibility point out that astrocytes might signify a massive new healing goal within the keep an eye on of epilepsy.
Astrocytes and Epilepsy comprises heritage explanatory textual content on astrocyte morphology and body structure, epilepsy versions and syndromes, and proof from either human tissue stories and animal types linking practical alterations in astrocytes to epilepsy. fantastically labelled diagrams are offered and suitable figures from the literature are reproduced to explain key findings and ideas during this quickly rising box. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators in addition to neurologists and different experts taking good care of sufferers with epilepsy.
- Presents the 1st complete publication to synthesize historic and up to date learn on astrocytes and epilepsy into one coherent volume
- Provides a very good source at the box of astrocyte biology and astrocyte-neuron interactions
- Details capability healing pursuits, together with chapters on hole junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation
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